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What the FDA labels say about taking them together

Disopyramide and quinine

Quinine's FDA label of November 9, 2023 names disopyramide in its warnings and precautions (prescription label) section; the disopyramide label PlainMeds reads does not name quinine. The quinine label: “Quinine sulfate is not recommended for use with other drugs known to cause QT prolongation, including Class IA antiarrhythmic agents, and Class III antiarrhythmic agents.”

Check it at the source: the disopyramide FDA label on DailyMed (effective August 24, 2026, Pfizer Laboratories Div Pfizer Inc); the quinine FDA label on DailyMed (effective November 9, 2023).

What does the disopyramide label say about quinine?

Disopyramide's label (effective August 24, 2026) does not name quinine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Norpace), Pfizer Laboratories Div Pfizer Inc, effective August 24, 2026 (SPL set e2aa1642-d262-4520-bc6a-9fd3ad795677), via openFDA; the full label on DailyMed

What does the quinine label say about disopyramide?

Quinine label, warnings and precautions (prescription label)

Quinine sulfate is not recommended for use with other drugs known to cause QT prolongation, including Class IA antiarrhythmic agents (e.g., quinidine, procainamide, disopyramide), and Class III antiarrhythmic agents (e.g., amiodarone, sotalol, dofetilide).

Source: FDA drug label (Chininum sulphuricum), Boiron, effective November 9, 2023 (SPL set 33885950-2a55-11e7-8288-424c58303031), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

2Disopyramide generic labelers
4Quinine generic labelers
DisopyramideQuinine
Labeled forn/an/a
Boxed warningYesYes
Pharmacy cost (NADAC)$0.801 per capsule 100 mg capsule$0.698 per capsule 324 mg capsule
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?