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What the FDA labels say about taking them together

Disopyramide and fosamprenavir

Fosamprenavir's FDA label of September 15, 2023 names disopyramide in its drug interactions section; the disopyramide label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Therapeutic concentration monitoring, if available, is recommended for antiarrhythmics.”

Check it at the source: the disopyramide FDA label on DailyMed (effective August 24, 2026, Pfizer Laboratories Div Pfizer Inc); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).

What does the disopyramide label say about fosamprenavir?

Disopyramide's label (effective August 24, 2026) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Norpace), Pfizer Laboratories Div Pfizer Inc, effective August 24, 2026 (SPL set e2aa1642-d262-4520-bc6a-9fd3ad795677), via openFDA; the full label on DailyMed

What does the fosamprenavir label say about disopyramide?

Fosamprenavir label, drug interactions

Concomitant Drug Class/Drug Name: Antiarrhythmics: Amiodarone, disopyramide, lidocaine (systemic), and quinidine; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Antiarrhythmics; Clinical Comment: Therapeutic concentration monitoring, if available, is recommended for antiarrhythmics.

Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

2Disopyramide generic labelers
2Fosamprenavir generic labelers
DisopyramideFosamprenavir
Labeled forn/aHIV
Boxed warningYesNo
Pharmacy cost (NADAC)$0.801 per capsule 100 mg capsulen/a
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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