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What the FDA labels say about taking them together

Disopyramide and etravirine

Etravirine's FDA label of August 15, 2023 names disopyramide in its drug interactions section; the disopyramide label PlainMeds reads does not name etravirine. The etravirine label: “Concentrations of these antiarrhythmics may be decreased when co-administered with INTELENCE. INTELENCE and antiarrhythmics should be co-administered with caution. …”

Check it at the source: the disopyramide FDA label on DailyMed (effective August 24, 2026, Pfizer Laboratories Div Pfizer Inc); the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP).

What does the disopyramide label say about etravirine?

Disopyramide's label (effective August 24, 2026) does not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Norpace), Pfizer Laboratories Div Pfizer Inc, effective August 24, 2026 (SPL set e2aa1642-d262-4520-bc6a-9fd3ad795677), via openFDA; the full label on DailyMed

What does the etravirine label say about disopyramide?

Etravirine label, drug interactions

Concomitant Drug Class/Drug Name: amiodarone bepridil disopyramide flecainide lidocaine (systemic) mexiletine propafenone quinidine; Effect on Concentration of Etravirine or Concomitant Drug: ↓ antiarrhythmics; Clinical Comment: Concentrations of these antiarrhythmics may be decreased when co-administered with INTELENCE. INTELENCE and antiarrhythmics should be co-administered with caution. Drug concentration monitoring is recommended, if available.

Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

2Disopyramide generic labelers
5Etravirine generic labelers
DisopyramideEtravirine
Labeled forn/aHIV
Boxed warningYesNo
Pharmacy cost (NADAC)$0.801 per capsule 100 mg capsule$9.94 per tablet 200 mg tablet
Shortage nowA presentation being discontinuedA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?