What the FDA labels say about taking them together
Atropine/diphenoxylate and buspirone
Atropine/diphenoxylate's FDA label of February 23, 2026 names buspirone in its drug interactions section; the buspirone label PlainMeds reads does not name atropine/diphenoxylate.
Check it at the source: the atropine/diphenoxylate FDA label on DailyMed (effective February 23, 2026, Pfizer Laboratories Div Pfizer Inc); the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.).
What does the atropine/diphenoxylate label say about buspirone?
Atropine/diphenoxylate label, drug interactionsOther Drugs that Cause CNS Depression The concurrent use of Lomotil with other drugs that cause CNS depression (e.g., barbiturates, benzodiazepines, opioids, buspirone, antihistamines, muscle relaxants), may potentiate the effects of Lomotil (see WARNINGS ).
Source: FDA drug label (Lomotil), Pfizer Laboratories Div Pfizer Inc, effective February 23, 2026 (SPL set f170584a-1072-4fd7-b1dc-6756703483b9), via openFDA; the full label on DailyMed
What does the buspirone label say about atropine/diphenoxylate?
Buspirone's label (effective December 22, 2023) does not name atropine/diphenoxylate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atropine/diphenoxylate | Buspirone | |
|---|---|---|
| Labeled for | Diarrhea | Anxiety |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.139 per tablet 2.5-0.025 mg tablet | $0.043 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once