What the FDA labels say about taking them together
Dihydroergotamine and rizatriptan
Rizatriptan's FDA label of January 29, 2026 names dihydroergotamine in its contraindications section; the dihydroergotamine labels PlainMeds reads (4) do not name rizatriptan. The rizatriptan label: “Because these effects may be additive, use of ergotamine-containing or ergot-type medications and MAXALT within 24 hours is contraindicated.”
Check it at the source: the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals); the rizatriptan FDA label on DailyMed (effective January 29, 2026).
What does the dihydroergotamine label say about rizatriptan?
Dihydroergotamine's label (effective March 6, 2025) and its 3 other brand-application labels do not name rizatriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
What does the rizatriptan label say about dihydroergotamine?
Rizatriptan label, contraindicationsRecent use (i.e., within 24 hours) of another 5-HT 1 agonist, ergotamine-containing medication, or ergot-type medication (such as dihydroergotamine or methysergide) [see Drug Interactions (7.2 and 7.3) ].
Rizatriptan label, drug interactionsBecause these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and MAXALT within 24 hours is contraindicated [see Contraindications (4) ].
Source: FDA drug label (Rizafilm, NDA205394), Gensco Laboratories LLC, effective April 27, 2025 (SPL set fa32794e-d26d-e0bf-e053-6294a90abb0e), via openFDA
Source: FDA drug label (MAXALT), Organon LLC, effective January 29, 2026 (SPL set 007b4644-e0e7-4863-9ae3-fe09676b3f5f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dihydroergotamine | Rizatriptan | |
|---|---|---|
| Labeled for | Migraine | Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $29.44 per mL 4 mg/mL nasal spray | $0.335 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once