What the FDA labels say about taking them together
Dihydroergotamine and lenacapavir
Lenacapavir's FDA label of August 27, 2026 names dihydroergotamine in its drug interactions section; the dihydroergotamine labels PlainMeds reads (4) do not name lenacapavir. The lenacapavir label: “Concomitant administration of SUNLENCA with dihydroergotamine, ergotamine or methylergonovine is not recommended.”
Check it at the source: the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals); the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.).
What does the dihydroergotamine label say about lenacapavir?
Dihydroergotamine's label (effective March 6, 2025) and its 3 other brand-application labels do not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
What does the lenacapavir label say about dihydroergotamine?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Ergot derivatives: dihydroergotamine ergotamine methylergonovine; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ dihydroergotamine ↑ ergotamine ↑ methylergonovine; Clinical Comment: Concomitant administration of SUNLENCA with dihydroergotamine, ergotamine or methylergonovine is not recommended.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dihydroergotamine | Lenacapavir | |
|---|---|---|
| Labeled for | Migraine | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $29.44 per mL 4 mg/mL nasal spray | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once