What the FDA labels say about taking them together
Dihydroergotamine and frovatriptan
Frovatriptan's FDA label of June 27, 2026 names dihydroergotamine in its contraindications section; the dihydroergotamine labels PlainMeds reads (4) do not name frovatriptan. The frovatriptan label: “Because these effects may be additive, use of ergotamine-containing or ergot-type medications and frovatriptan succinate within 24 hours of each other is contraindicated [ see Contraindications ].”
Check it at the source: the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals); the frovatriptan FDA label on DailyMed (effective June 27, 2026, Leading Pharma, LLC).
What does the dihydroergotamine label say about frovatriptan?
Dihydroergotamine's label (effective March 6, 2025) and its 3 other brand-application labels do not name frovatriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
What does the frovatriptan label say about dihydroergotamine?
Frovatriptan label, contraindicationsRecent use (i.e., within 24 hours) of another 5-HT 1 agonist, an ergotamine containing or ergot-type medication such as dihydroergotamine (DHE) or methysergide [see Drug Interactions (7.1 , 7.2) ].
Frovatriptan label, drug interactionsBecause these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and frovatriptan succinate within 24 hours of each other is contraindicated [ see Contraindications (4) ].
Source: FDA drug label (FROVATRIPTAN SUCCINATE), Leading Pharma, LLC, effective June 27, 2026 (SPL set d303af88-e0c1-4fb2-ba8e-83b7e6d163cd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dihydroergotamine | Frovatriptan | |
|---|---|---|
| Labeled for | Migraine | Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $29.44 per mL 4 mg/mL nasal spray | $2.72 per tablet 2.5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once