What the FDA labels say about taking them together
Dihydroergotamine and ergotamine
Dihydroergotamine's FDA label of March 6, 2025 names ergotamine in its drug interactions section; the ergotamine label PlainMeds reads does not name dihydroergotamine.
Check it at the source: the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals); the ergotamine FDA label on DailyMed (effective February 25, 2025, Pangea Pharmaceuticals LLC).
What does the dihydroergotamine label say about ergotamine?
Dihydroergotamine label, drug interactionsBeta-Blockers Although the results of a clinical study did not indicate a safety problem associated with the administration of Dihydroergotamine Mesylate Nasal Spray to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.
Trudhesa label (Impel Pharmaceuticals LLC, September 3, 2026), drug interactionsThere have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.
Source: FDA drug label (Trudhesa, NDA213436), Impel Pharmaceuticals LLC, effective September 3, 2026 (SPL set b81397b0-910d-4eb4-8fee-a9a3c9d94d63), via openFDA
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
What does the ergotamine label say about dihydroergotamine?
Ergotamine's label (effective February 25, 2025) does not name dihydroergotamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ergomar Sublingual), Pangea Pharmaceuticals LLC, effective February 25, 2025 (SPL set a9582fdb-7ddd-4f69-aa7a-66247cdb8c92), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dihydroergotamine | Ergotamine | |
|---|---|---|
| Labeled for | Migraine | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $29.44 per mL 4 mg/mL nasal spray | $43.46 per tablet 2 mg tablet sublingual |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once