What the FDA labels say about taking them together
Dihydroergotamine and eletriptan
Eletriptan's FDA label of November 27, 2024 names dihydroergotamine in its contraindications section; the dihydroergotamine labels PlainMeds reads (4) do not name eletriptan. The eletriptan label: “Because these effects may be additive, use of ergotamine-containing or ergot-type medications and RELPAX within 24 hours of each other is contraindicated.”
Check it at the source: the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals); the eletriptan FDA label on DailyMed (effective November 27, 2024, Teva Pharmaceuticals USA, Inc.).
What does the dihydroergotamine label say about eletriptan?
Dihydroergotamine's label (effective March 6, 2025) and its 3 other brand-application labels do not name eletriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
What does the eletriptan label say about dihydroergotamine?
Eletriptan label, contraindicationsRecent use (i.e., within 24 hours) of another 5-hydroxytryptamine 1 (5-HT 1 ) agonist, ergotamine-containing medication, or ergot-type medication such as dihydroergotamine (DHE) or methysergide [see Drug Interactions ( 7.1 )].
Eletriptan label, drug interactionsBecause these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine [DHE] or methysergide) and eletriptan hydrobromide within 24 hours of each other is contraindicated.
Source: FDA drug label (Relpax, NDA021016), Viatris Specialty LLC, effective January 15, 2024 (SPL set 2a501dbd-3ea8-47e4-9fcb-07035b8c8c9e), via openFDA
Source: FDA drug label (Eletriptan Hydrobromide), Teva Pharmaceuticals USA, Inc., effective November 27, 2024 (SPL set 62dc12ce-4f19-41c6-9593-3cae29f04af1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dihydroergotamine | Eletriptan | |
|---|---|---|
| Labeled for | Migraine | Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $29.44 per mL 4 mg/mL nasal spray | $1.75 per tablet 40 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once