Diflunisal and Acetaminophen Interaction
Drug interaction information between Diflunisal and Acetaminophen.
Diflunisal and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diflunisal and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diflunisal causes the levels of acetaminophen in your blood to go up by about half. This could increase the risk of liver damage from the acetaminophen.
FDA Label Information
Acetaminophen In normal volunteers, concomitant administration of diflunisal and acetaminophen resulted in an approximate 50% increase in plasma levels of acetaminophen. Acetaminophen had no effect on plasma levels of diflunisal. Since acetaminophen in high doses has been associated with hepatotoxicity, concomitant administration of diflunisal tablets and acetaminophen should be used cautiously, with careful monitoring of patients.
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
What SPL severity band is on file for Diflunisal + Acetaminophen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen has 23 labeled pairs on file vs Diflunisal's 17. In the minor band specifically: Diflunisal has 6 (also Hydrochlorothiazide, Furosemide, Aspirin, Lithium); Acetaminophen has 21 (also Acetaminophen/Oxycodone, Carbamazepine, Cidofovir, Codeine).
What mechanism field is on file for Diflunisal and Acetaminophen?
Diflunisal causes the levels of acetaminophen in your blood to go up by about half. This could increase the risk of liver damage from the acetaminophen.
Acetaminophen's labeled portfolio outnumbers Diflunisal
SPL source-record counts only. This page's band is minor · classes on file: Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Acetaminophen (Analgesic / Antipyretic).
0 major · 11 moderate · 6 minor · 17 total
- Other minor peers for Diflunisal
- Hydrochlorothiazide
- Furosemide
- Aspirin
- Lithium
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Cidofovir
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.