What the FDA labels say about taking them together
Dienogest/estradiol and topiramate
Dienogest/estradiol's FDA label of June 26, 2024 names topiramate in its drug interactions section; the topiramate labels PlainMeds reads (4) do not name dienogest/estradiol. The dienogest/estradiol label: “… carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St. John’s wort.”
Check it at the source: the dienogest/estradiol FDA label on DailyMed (effective June 26, 2024, Bayer HealthCare Pharmaceuticals Inc.); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the dienogest/estradiol label say about topiramate?
Dienogest/estradiol label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St. John’s wort.
Source: FDA drug label (Natazia), Bayer HealthCare Pharmaceuticals Inc., effective June 26, 2024 (SPL set 02c91fba-9c47-43ef-ac78-e82369798834), via openFDA; the full label on DailyMed
What does the topiramate label say about dienogest/estradiol?
Topiramate's label (effective June 1, 2026) and its 3 other brand-application labels do not name dienogest/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dienogest/estradiol | Topiramate | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $8.46 per tablet 28 tablet | $0.0567 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once