What the FDA labels say about taking them together
Dienogest/estradiol and lamotrigine
Dienogest/estradiol's FDA label of June 26, 2024 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name dienogest/estradiol. The dienogest/estradiol label: “COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.”
Check it at the source: the dienogest/estradiol FDA label on DailyMed (effective June 26, 2024, Bayer HealthCare Pharmaceuticals Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the dienogest/estradiol label say about lamotrigine?
Dienogest/estradiol label, drug interactionsCOCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.
Source: FDA drug label (Natazia), Bayer HealthCare Pharmaceuticals Inc., effective June 26, 2024 (SPL set 02c91fba-9c47-43ef-ac78-e82369798834), via openFDA; the full label on DailyMed
What does the lamotrigine label say about dienogest/estradiol?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name dienogest/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dienogest/estradiol | Lamotrigine | |
|---|---|---|
| Labeled for | Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $8.46 per tablet 28 tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once