What the FDA labels say about taking them together
Dienogest/estradiol and fluconazole
Dienogest/estradiol's FDA label of June 26, 2024 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name dienogest/estradiol. The dienogest/estradiol label: “Concomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals, verapamil, macrolides, diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest.”
Check it at the source: the dienogest/estradiol FDA label on DailyMed (effective June 26, 2024, Bayer HealthCare Pharmaceuticals Inc.); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the dienogest/estradiol label say about fluconazole?
Dienogest/estradiol label, drug interactionsConcomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest.
Source: FDA drug label (Natazia), Bayer HealthCare Pharmaceuticals Inc., effective June 26, 2024 (SPL set 02c91fba-9c47-43ef-ac78-e82369798834), via openFDA; the full label on DailyMed
What does the fluconazole label say about dienogest/estradiol?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name dienogest/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dienogest/estradiol | Fluconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $8.46 per tablet 28 tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once