What the FDA labels say about taking them together
Dicyclomine and meperidine
Dicyclomine's FDA label of August 6, 2026 names meperidine in its drug interactions section; the meperidine labels PlainMeds reads (2) do not name dicyclomine. The dicyclomine label: “… phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.”
Check it at the source: the dicyclomine FDA label on DailyMed (effective August 6, 2026, Lannett Company, LLC); the meperidine FDA label on DailyMed (effective November 29, 2025, EPIC PHARMA, LLC).
What does the dicyclomine label say about meperidine?
Dicyclomine label, drug interactionsDrugs with Anticholinergic Activity The following agents may increase certain actions or side effects of anticholinergic drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity.
Source: FDA drug label (Dicyclomine Hydrochloride), Lannett Company, LLC, effective August 6, 2026 (SPL set bd2cba10-70ec-4d1f-b46c-53d1de2ee130), via openFDA; the full label on DailyMed
What does the meperidine label say about dicyclomine?
Meperidine's label (effective November 29, 2025) and its 1 other brand-application label do not name dicyclomine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Meperidine Hydrochloride), EPIC PHARMA, LLC, effective November 29, 2025 (SPL set fae5cc34-5917-4445-9516-25f97ffca8db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dicyclomine | Meperidine | |
|---|---|---|
| Labeled for | Irritable bowel syndrome | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.059 per tablet 20 mg tablet | $0.157 per mL 50 mg/5 mL solution |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once