What the FDA labels say about taking them together
Diclofenac and ibuprofen
Diclofenac's FDA label of February 11, 2025 names ibuprofen in its warnings section, and ibuprofen's label names diclofenac too.
Check it at the source: the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC); the ibuprofen FDA label on DailyMed (effective January 1, 2026, Savings Distributors LLC).
What does the diclofenac label say about ibuprofen?
Diclofenac label, warningstake other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
What does the ibuprofen label say about diclofenac?
Caldolor label (Cumberland Pharmaceuticals Inc., January 29, 2026), drug interactionsNSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Source: FDA drug label (Caldolor, NDA022348), Cumberland Pharmaceuticals Inc., effective January 29, 2026 (SPL set 1eaa7790-f1a1-4f51-b10a-cbbaf033f684), via openFDA
Source: FDA drug label (Motrin IB), NDA019012 (Kenvue Brands), as published by Savings Distributors LLC, effective January 1, 2026 (SPL set 56846774-8413-c306-e063-6394a90a2be8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diclofenac | Ibuprofen | |
|---|---|---|
| Labeled for | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine | Fever, Osteoarthritis, Rheumatoid arthritis, Pain, Cough and cold |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0619 per tablet 75 mg tablet | $0.0573 per tablet 800 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once