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What the FDA labels say about taking them together

Dichlorphenamide and theophylline

Dichlorphenamide's FDA label of March 4, 2026 names theophylline in its drug interactions section; the theophylline label PlainMeds reads does not name dichlorphenamide. The dichlorphenamide label: “Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia.”

Check it at the source: the dichlorphenamide FDA label on DailyMed (effective March 4, 2026, Xeris Pharmaceuticals, Inc.); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).

What does the dichlorphenamide label say about theophylline?

Dichlorphenamide label, drug interactions

Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ].

Source: FDA drug label (Keveyis), Xeris Pharmaceuticals, Inc., effective March 4, 2026 (SPL set d30a87b9-90fb-35b2-e053-2995a90aea2c), via openFDA; the full label on DailyMed

What does the theophylline label say about dichlorphenamide?

Theophylline's label (effective March 10, 2026) does not name dichlorphenamide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

3Dichlorphenamide generic labelers
26Theophylline generic labelers
DichlorphenamideTheophylline
Labeled forn/aAsthma
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$0.330 per tablet 300 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?