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What the FDA labels say about taking them together

Dichlorphenamide and oseltamivir

Dichlorphenamide's FDA label of March 4, 2026 names oseltamivir in its drug interactions section; the oseltamivir label PlainMeds reads does not name dichlorphenamide. The dichlorphenamide label: “Use of KEVEYIS with drugs that are sensitive to OAT1 inhibition is not recommended.”

Check it at the source: the dichlorphenamide FDA label on DailyMed (effective March 4, 2026, Xeris Pharmaceuticals, Inc.); the oseltamivir FDA label on DailyMed (effective December 15, 2025, Genentech, Inc.).

What does the dichlorphenamide label say about oseltamivir?

Dichlorphenamide label, drug interactions

Use of KEVEYIS with drugs that are sensitive to OAT1 inhibition (e.g., methotrexate, famotidine, oseltamivir) is not recommended [see Clinical Pharmacology (12.3) ].

Source: FDA drug label (Keveyis), Xeris Pharmaceuticals, Inc., effective March 4, 2026 (SPL set d30a87b9-90fb-35b2-e053-2995a90aea2c), via openFDA; the full label on DailyMed

What does the oseltamivir label say about dichlorphenamide?

Oseltamivir's label (effective December 15, 2025) does not name dichlorphenamide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Tamiflu), NDA021087 (Roche), as published by Genentech, Inc., effective December 15, 2025 (SPL set ee3c9555-60f2-4f82-a760-11983c86e97b), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

3Dichlorphenamide generic labelers
36Oseltamivir generic labelers
DichlorphenamideOseltamivir
Labeled forn/aInfluenza
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$0.150 per mL 6 mg/mL suspension
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?