What the FDA labels say about taking them together
Dichlorphenamide and methotrexate
Dichlorphenamide's FDA label of March 4, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name dichlorphenamide. The dichlorphenamide label: “Use of KEVEYIS with drugs that are sensitive to OAT1 inhibition is not recommended.”
Check it at the source: the dichlorphenamide FDA label on DailyMed (effective March 4, 2026, Xeris Pharmaceuticals, Inc.); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the dichlorphenamide label say about methotrexate?
Dichlorphenamide label, drug interactionsUse of KEVEYIS with drugs that are sensitive to OAT1 inhibition (e.g., methotrexate, famotidine, oseltamivir) is not recommended [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Keveyis), Xeris Pharmaceuticals, Inc., effective March 4, 2026 (SPL set d30a87b9-90fb-35b2-e053-2995a90aea2c), via openFDA; the full label on DailyMed
What does the methotrexate label say about dichlorphenamide?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name dichlorphenamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dichlorphenamide | Methotrexate | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once