What the FDA labels say about taking them together
Diazepam and stiripentol
Stiripentol's FDA label of April 27, 2026 names diazepam in its drug interactions section; the diazepam labels PlainMeds reads (4) do not name stiripentol. The stiripentol label: “Because of potential inhibition of enzyme/transporter activity, consider a reduction in dosage of substrates of CYP2C8, CYP2C19, P-gp (e.g., carbamazepine), and BCRP, if adverse reactions are experienced when …”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).
What does the diazepam label say about stiripentol?
Diazepam's label (effective August 11, 2026) and its 3 other brand-application labels do not name stiripentol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the stiripentol label say about diazepam?
Stiripentol label, drug interactionsBecause of potential inhibition of enzyme/transporter activity, consider a reduction in dosage of substrates of CYP2C8, CYP2C19 (e.g., diazepam, clopidogrel), P-gp (e.g., carbamazepine), and BCRP (e.g., methotrexate, prazosin, glyburide), if adverse reactions are experienced when administered concomitantly with DIACOMIT.
Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Stiripentol | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once