What the FDA labels say about taking them together
Diazepam and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names diazepam in its drug interactions section; the diazepam labels PlainMeds reads (4) do not name fosamprenavir. The fosamprenavir label: “Clinical significance is unknown. A decrease in benzodiazepine dose may be needed.”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the diazepam label say about fosamprenavir?
Diazepam's label (effective August 11, 2026) and its 3 other brand-application labels do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about diazepam?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Benzodiazepines: Alprazolam, clorazepate, diazepam, flurazepam; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Benzodiazepines; Clinical Comment: Clinical significance is unknown. A decrease in benzodiazepine dose may be needed.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Fosamprenavir | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once