What the FDA labels say about taking them together
Diazepam and flumazenil
Diazepam's FDA label of August 11, 2026 names flumazenil in its warnings section; flumazenil's label does not name diazepam itself but warns about its class (Benzodiazepines). The diazepam label: “… discontinuation or rapid dosage reduction of VALTOCO, or administration of flumazenil may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures).”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the flumazenil FDA label on DailyMed (effective June 21, 2024, Hikma Pharmaceuticals USA Inc.).
What does the diazepam label say about flumazenil?
Diazepam label, warningsAbrupt discontinuation or rapid dosage reduction of Valium after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) (see DRUG ABUSE AND DEPENDENCE:
Valtoco label (Neurelis, Inc, June 3, 2026), warnings and precautionsAlthough VALTOCO is indicated only for intermittent use [see Indications and Usage (1) and Dosage and Administration (2) ], if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction of VALTOCO, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) [see Drug Abuse and Dependence (9.3) ].
Source: FDA drug label (Valtoco, NDA211635), Neurelis, Inc, effective June 3, 2026 (SPL set 1a8bcc90-68fa-474d-832c-0df01e825f39), via openFDA
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the flumazenil label say about diazepam?
Flumazenil's label does not name diazepam itself; it warns about its class (Benzodiazepines):
Flumazenil label, contraindicationsCONTRAINDICATIONS Flumazenil is contraindicated: in patients with a known hypersensitivity to flumazenil or benzodiazepines. in patients who have been given a benzodiazepine for control of a potentially life-threatening condition (e.g., control of intracranial pressure or status epilepticus). in patients who are showing signs of serious cyclic antidepressant overdose (see WARNINGS ).
Flumazenil label, boxed warningTHESE ARE MOST FREQUENT IN PATIENTS WHO HAVE BEEN ON BENZODIAZEPINES FOR LONG-TERM SEDATION OR IN OVERDOSE CASES WHERE PATIENTS ARE SHOWING SIGNS OF SERIOUS CYCLIC ANTIDEPRESSANT OVERDOSE.
Source: FDA drug label (Flumazenil), Hikma Pharmaceuticals USA Inc., effective June 21, 2024 (SPL set 436f5616-9626-4b6a-9deb-2986444179d0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Flumazenil | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | $1.18 per mL 0.5 mg/5 mL vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once