What the FDA labels say about taking them together
Diazepam and divalproex
Divalproex's FDA label of March 31, 2026 names diazepam in its drug interactions section; diazepam's label does not name divalproex itself but warns about its class (Anti-seizure medicines). The divalproex label: “Monitoring of valproate concentrations is recommended Co-administration of valproate can affect the pharmacokinetics of other drugs by inhibiting their metabolism or protein binding displacement Patients stabilized on …”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.).
What does the diazepam label say about divalproex?
Diazepam's label does not name divalproex itself; it warns about its class (Anti-seizure medicines):
Diazepam label, warnings and precautionsBehavior and Ideation Antiepileptic drugs (AEDs), including VALTOCO, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Diazepam label, warnings and precautionsPatients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the divalproex label say about diazepam?
Divalproex label, drug interactionsMonitoring of valproate concentrations is recommended ( 7.1 ) Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g., diazepam, ethosuximide, lamotrigine, phenytoin) by inhibiting their metabolism or protein binding displacement ( 7.2 ) Patients stabilized on rufinamide should begin valproate therapy at a low dose, and titrate to clinically effective dose ( 7.2 ) Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with Depakote ( 7.2 ) Topiramate:
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Divalproex | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | Bipolar disorder, Migraine, Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | $0.194 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once