What the FDA labels say about taking them together
Dextroamphetamine and sodium bicarbonate
Dextroamphetamine's FDA label of November 26, 2025 names sodium bicarbonate in its drug interactions section; the sodium bicarbonate labels PlainMeds reads (3) do not name dextroamphetamine. The dextroamphetamine label: “Alkalinizing Agent Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines.”
Check it at the source: the dextroamphetamine FDA label on DailyMed (effective November 26, 2025, Azurity Pharmaceuticals, Inc.); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the dextroamphetamine label say about sodium bicarbonate?
Dextroamphetamine label, drug interactionsAlkalinizing Agent Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines.
Source: FDA drug label (Zenzedi), Azurity Pharmaceuticals, Inc., effective November 26, 2025 (SPL set d6394df5-f2c9-47eb-b57e-f3e9cfd94f84), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about dextroamphetamine?
Sodium bicarbonate's label (effective August 4, 2026) and its 2 other brand-application labels do not name dextroamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextroamphetamine | Sodium bicarbonate | |
|---|---|---|
| Labeled for | ADHD | Acid reflux and ulcers, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.373 per tablet 10 mg tablet | $0.154 per mL 8.4% vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once