What the FDA labels say about taking them together
Dextroamphetamine and fentanyl
Dextroamphetamine's FDA label of November 26, 2025 names fentanyl in its drug interactions section; the fentanyl labels PlainMeds reads (2) do not name dextroamphetamine. The dextroamphetamine label: “… norepinephrine reuptake inhibitors (SNRI), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort.”
Check it at the source: the dextroamphetamine FDA label on DailyMed (effective November 26, 2025, Azurity Pharmaceuticals, Inc.); the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.).
What does the dextroamphetamine label say about fentanyl?
Dextroamphetamine label, drug interactionsIf serotonin syndrome occurs, discontinue dextroamphetamine sulfate tablets and the concomitant serotonergic drug (s) (see WARNINGS and PRECAUTIONS ). Examples of serotonergic drugs include selective serotonin reuptake inhibitors (SSRI), serotonin norepinephrine reuptake inhibitors (SNRI), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort.
Dextroamphetamine label, warningsSerotonin Syndrome Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort (see Drug Interactions ).
Source: FDA drug label (Xelstrym, NDA215401), Noven Therapeutics, LLC, effective December 23, 2025 (SPL set 0862f02a-72a8-41cc-8845-57cf4974bb6f), via openFDA
Source: FDA drug label (Zenzedi), Azurity Pharmaceuticals, Inc., effective November 26, 2025 (SPL set d6394df5-f2c9-47eb-b57e-f3e9cfd94f84), via openFDA; the full label on DailyMed
What does the fentanyl label say about dextroamphetamine?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name dextroamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextroamphetamine | Fentanyl | |
|---|---|---|
| Labeled for | ADHD | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.373 per tablet 10 mg tablet | $1.79 per mL 100 mcg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once