What the FDA labels say about taking them together
Dexamethasone and rilpivirine
Rilpivirine's FDA label of August 28, 2025 names dexamethasone in its contraindications section; the dexamethasone labels PlainMeds reads (4) do not name rilpivirine. The rilpivirine label: “Coadministration is contraindicated with EDURANT or EDURANT PED.”
Check it at the source: the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the dexamethasone label say about rilpivirine?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
What does the rilpivirine label say about dexamethasone?
Rilpivirine label, contraindicationsDrug Class: Glucocorticoid (systemic); Contraindicated Drugs in Class: Dexamethasone (more than a single-dose treatment); Clinical Comment: Potential for significant decreases in rilpivirine plasma concentrations due to CYP3A enzyme induction, which may result in loss of virologic response.
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Glucocorticoid (systemic): dexamethasone (more than a single-dose treatment); Effect on Concentration of Rilpivirine or Concomitant Drug: ↓ rilpivirine; Clinical Comment: Coadministration is contraindicated with EDURANT or EDURANT PED [see ].
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexamethasone | Rilpivirine | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 4 mg tablet | $48.04 per tablet 25 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once