What the FDA labels say about taking them together
Dexamethasone and pegaspargase
Pegaspargase's FDA label of October 7, 2024 names dexamethasone in its drug interactions section; the dexamethasone labels PlainMeds reads (4) do not name pegaspargase. The pegaspargase label: “DRUG INTERACTIONS 7.1 Glucocorticoids Pegaspargase may increase the risk of glucocorticoid-induced toxicities, including osteonecrosis through a potential increase in exposure of dexamethasone.”
Check it at the source: the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.); the pegaspargase FDA label on DailyMed (effective October 7, 2024, Servier Pharmaceuticals LLC).
What does the dexamethasone label say about pegaspargase?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name pegaspargase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
What does the pegaspargase label say about dexamethasone?
Pegaspargase label, drug interactionsDRUG INTERACTIONS 7.1 Glucocorticoids Pegaspargase may increase the risk of glucocorticoid-induced toxicities, including osteonecrosis through a potential increase in exposure of dexamethasone [see Adverse Reactions (6.3) ].
Source: FDA drug label (ONCASPAR), BLA103411 (Sigma Tau), as published by Servier Pharmaceuticals LLC, effective October 7, 2024 (SPL set ac7b6a6f-6ddb-48c6-8088-d8a8e3fea6ce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexamethasone | Pegaspargase | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain | Leukemia, lymphoma and myeloma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 4 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once