What the FDA labels say about taking them together
Dexamethasone and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names dexamethasone in its drug interactions section; the dexamethasone labels PlainMeds reads (4) do not name fosamprenavir. The fosamprenavir label: “Use with caution. Fosamprenavir may be less effective due to decreased amprenavir plasma concentrations.”
Check it at the source: the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the dexamethasone label say about fosamprenavir?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about dexamethasone?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Corticosteroid: Dexamethasone; Effect on Concentration of Amprenavir or Concomitant Drug: ↓ Amprenavir; Clinical Comment: Use with caution. Fosamprenavir may be less effective due to decreased amprenavir plasma concentrations.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexamethasone | Fosamprenavir | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 4 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once