What the FDA labels say about taking them together
Dexamethasone and etravirine
Etravirine's FDA label of August 15, 2023 names dexamethasone in its drug interactions section; the dexamethasone labels PlainMeds reads (4) do not name etravirine. The etravirine label: “Systemic dexamethasone induces CYP3A and can decrease etravirine plasma concentrations. This may result in loss of therapeutic effect of INTELENCE. …”
Check it at the source: the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.); the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP).
What does the dexamethasone label say about etravirine?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
What does the etravirine label say about dexamethasone?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: Corticosteroid: dexamethasone (systemic); Effect on Concentration of Etravirine or Concomitant Drug: ↓ etravirine; Clinical Comment: Systemic dexamethasone induces CYP3A and can decrease etravirine plasma concentrations. This may result in loss of therapeutic effect of INTELENCE. Systemic dexamethasone should be used with caution or alternatives should be considered, particularly for long-term use.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexamethasone | Etravirine | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 4 mg tablet | $9.94 per tablet 200 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once