What the FDA labels say about taking them together
Dexamethasone and donepezil/memantine
Donepezil/memantine's FDA label of December 17, 2024 names dexamethasone in its drug interactions section; the dexamethasone labels PlainMeds reads (4) do not name donepezil/memantine. The donepezil/memantine label: “Inducers of CYP3A4 could increase the rate of elimination of donepezil.”
Check it at the source: the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.); the donepezil/memantine FDA label on DailyMed (effective December 17, 2024, Amneal Pharmaceuticals NY LLC).
What does the dexamethasone label say about donepezil/memantine?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name donepezil/memantine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
What does the donepezil/memantine label say about dexamethasone?
Donepezil/memantine label, drug interactionsInducers of CYP3A4 (e.g., phenytoin, carbamazepine, dexamethasone, rifampin, and phenobarbital) could increase the rate of elimination of donepezil.
Source: FDA drug label (Memantine and Donepezil Hydrochlorides Extended-release), Amneal Pharmaceuticals NY LLC, effective December 17, 2024 (SPL set 2335950c-be3b-4248-ad04-e9763aee47d2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexamethasone | Donepezil/memantine | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain | Alzheimer's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 4 mg tablet | $8.44 per unit 28-10 mg |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once