What the FDA labels say about taking them together
Deutivacaftor/tezacaftor/vanzacaftor and ivacaftor
Deutivacaftor/tezacaftor/vanzacaftor's FDA label of August 26, 2026 names ivacaftor in its boxed warning section; the ivacaftor label PlainMeds reads does not name deutivacaftor/tezacaftor/vanzacaftor. The deutivacaftor/tezacaftor/vanzacaftor label: “… taking a fixed-dose combination drug containing elexacaftor, tezacaftor, and ivacaftor, which contains the same or similar active ingredients as ALYFTREK.”
Check it at the source: the deutivacaftor/tezacaftor/vanzacaftor FDA label on DailyMed (effective August 26, 2026, Vertex Pharmaceuticals Incorporated); the ivacaftor FDA label on DailyMed (effective March 23, 2026, Vertex Pharmaceuticals Incorporated).
What does the deutivacaftor/tezacaftor/vanzacaftor label say about ivacaftor?
Deutivacaftor/tezacaftor/vanzacaftor label, boxed warningCases of serious and potentially fatal drug-induced liver injury and liver failure were reported in patients who were taking a fixed-dose combination drug containing elexacaftor, tezacaftor, and ivacaftor, which contains the same or similar active ingredients as ALYFTREK.
Deutivacaftor/tezacaftor/vanzacaftor label, drug interactionsHormonal Contraceptives No clinically significant differences in the pharmacokinetics of ethinyl estradiol/norethindrone containing hormonal contraceptives were observed when used concomitantly with tezacaftor in combination with ivacaftor and ivacaftor alone [see Clinical Pharmacology (12.3) ].
Deutivacaftor/tezacaftor/vanzacaftor label, warnings and precautionsReduce the ALYFTREK dosage with concomitant use. ( 2.3 , 5.7 , 7.1 ) Cataracts: Non-congenital lens opacities/cataracts have been reported in patients with CF aged 18 years or less treated with drugs containing ivacaftor.
Source: FDA drug label (ALYFTREK), Vertex Pharmaceuticals Incorporated, effective August 26, 2026 (SPL set 7e635909-c6fd-4f0d-ae77-cdff03653a20), via openFDA; the full label on DailyMed
What does the ivacaftor label say about deutivacaftor/tezacaftor/vanzacaftor?
Ivacaftor's label (effective March 23, 2026) does not name deutivacaftor/tezacaftor/vanzacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Kalydeco), Vertex Pharmaceuticals Incorporated, effective March 23, 2026 (SPL set 0ab0c9f8-3eee-4e0f-9f3f-c1e16aaffe25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deutivacaftor/tezacaftor/vanzacaftor | Ivacaftor | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once