What the FDA labels say about taking them together
Deutetrabenazine and paroxetine
Deutetrabenazine's FDA label of February 28, 2025 names paroxetine in its drug interactions section; the paroxetine labels PlainMeds reads (4) do not name deutetrabenazine. The deutetrabenazine label: “Concomitant use of strong CYP2D6 inhibitors has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.”
Check it at the source: the deutetrabenazine FDA label on DailyMed (effective February 28, 2025, Teva Neuroscience, Inc.); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the deutetrabenazine label say about paroxetine?
Deutetrabenazine label, drug interactionsConcomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Source: FDA drug label (Austedo), Teva Neuroscience, Inc., effective February 28, 2025 (SPL set 7ea3c60a-45c7-44cc-afc2-d87fa53993c0), via openFDA; the full label on DailyMed
What does the paroxetine label say about deutetrabenazine?
Paroxetine's label (effective February 12, 2026) and its 3 other brand-application labels do not name deutetrabenazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deutetrabenazine | Paroxetine | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety, Menopause symptoms |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $249.32 per unit 12-18-24-30 mg) | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once