What the FDA labels say about taking them together
Desvenlafaxine and nebivolol
Desvenlafaxine's FDA label of January 27, 2023 names nebivolol in its drug interactions section; the nebivolol label PlainMeds reads does not name desvenlafaxine. The desvenlafaxine label: “Substrates primarily metabolized by CYP2D6 should be dosed at the original level when co-administered with desvenlafaxine 100 mg or lower or when desvenlafaxine is discontinued.”
Check it at the source: the desvenlafaxine FDA label on DailyMed (effective January 27, 2023, Alembic Pharmaceuticals Limited); the nebivolol FDA label on DailyMed (effective August 1, 2024, Allergan, Inc.).
What does the desvenlafaxine label say about nebivolol?
Desvenlafaxine label, drug interactionsSubstrates primarily metabolized by CYP2D6 (e.g., desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine) should be dosed at the original level when co-administered with desvenlafaxine 100 mg or lower or when desvenlafaxine is discontinued.
Pristiq Extended-Release label (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., April 28, 2026), drug interactionsExamples; desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine
Source: FDA drug label (Pristiq Extended-Release, NDA021992), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective April 28, 2026 (SPL set 0f43610c-f290-46ea-d186-4f998ed99fce), via openFDA
Source: FDA drug label (Desvenlafaxine), Alembic Pharmaceuticals Limited, effective January 27, 2023 (SPL set 9f74708c-6f6a-46cf-8c79-87a25c2bb6f8), via openFDA; the full label on DailyMed
What does the nebivolol label say about desvenlafaxine?
Nebivolol's label (effective August 1, 2024) does not name desvenlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Bystolic), Allergan, Inc., effective August 1, 2024 (SPL set 8b8ad213-1dc8-454e-a524-075685c0e1a8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desvenlafaxine | Nebivolol | |
|---|---|---|
| Labeled for | Depression | High blood pressure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.396 per unit 50 mg | $0.141 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once