What the FDA labels say about taking them together
Desmopressin and oxybutynin
Desmopressin's FDA label (Desmoda) of March 2, 2026 names oxybutynin in its drug interactions section; the oxybutynin labels PlainMeds reads (2) do not name desmopressin. The desmopressin label: “DRUG INTERACTIONS 7.1 Other Drugs that may Increase Risk of Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia,.”
Check it at the source: the desmopressin FDA label on DailyMed (effective February 3, 2021, Ferring Pharmaceuticals Inc.); the oxybutynin FDA label on DailyMed (effective December 16, 2025, Accord Healthcare, Inc.).
What does the desmopressin label say about oxybutynin?
Desmoda label (Eton Pharmaceuticals, Inc., March 2, 2026), drug interactionsDRUG INTERACTIONS 7.1 Other Drugs that may Increase Risk of Hyponatremia Concomitant administration of DESMODA with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, thiazide diuretics, NSAIDs, lamotrigine, sulfonylureas, particularly chlorpropamide, oxybutynin and carbamazepine).
Source: FDA drug label (Desmoda, NDA219873), Eton Pharmaceuticals, Inc., effective March 2, 2026 (SPL set 4c0e1356-d14f-cfb4-e063-6294a90acd27), via openFDA
Source: FDA drug label (Desmopressin Acetate, NDA018938), Nordic Pharma, Inc., effective October 24, 2025 (SPL set 29df0492-f7ef-47bb-aa67-4ef9e5c2846f), via openFDA
Source: FDA drug label (DDAVP), Ferring Pharmaceuticals Inc., effective February 3, 2021 (SPL set 6d55baa9-2b62-469c-93ae-3909ab249332), via openFDA; the full label on DailyMed
What does the oxybutynin label say about desmopressin?
Oxybutynin's label (effective December 16, 2025) and its 1 other brand-application label do not name desmopressin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (oxybutynin chloride), Accord Healthcare, Inc., effective December 16, 2025 (SPL set 61496a1e-17bf-4f45-a20c-5bb98fe545ee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desmopressin | Oxybutynin | |
|---|---|---|
| Labeled for | n/a | Overactive bladder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $19.15 per mL 40 mcg/10 mL vial | $0.048 per tablet 5 mg tablet |
| Shortage now | Listed; available | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once