What the FDA labels say about taking them together
Desloratadine/pseudoephedrine and methyldopa
Desloratadine/pseudoephedrine's FDA label of November 12, 2025 names methyldopa in its drug interactions section; the methyldopa label PlainMeds reads does not name desloratadine/pseudoephedrine. The desloratadine/pseudoephedrine label: “The antihypertensive effects of beta-adrenergic blocking agents, methyldopa, and reserpine, may be reduced by sympathomimetics such as pseudoephedrine.”
Check it at the source: the desloratadine/pseudoephedrine FDA label on DailyMed (effective November 12, 2025); the methyldopa FDA label on DailyMed (effective March 26, 2025, Chartwell RX, LLC).
What does the desloratadine/pseudoephedrine label say about methyldopa?
Desloratadine/pseudoephedrine label, drug interactionsThe antihypertensive effects of beta-adrenergic blocking agents, methyldopa, and reserpine, may be reduced by sympathomimetics such as pseudoephedrine.
Source: FDA drug label (CLARINEX-D 12 HOUR), Organon LLC, effective November 12, 2025 (SPL set 1af66b7a-4ab8-40d8-abdd-22d3310228a8), via openFDA; the full label on DailyMed
What does the methyldopa label say about desloratadine/pseudoephedrine?
Methyldopa's label (effective March 26, 2025) does not name desloratadine/pseudoephedrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methyldopa), Chartwell RX, LLC, effective March 26, 2025 (SPL set e1114a58-9ab5-486e-85ed-360365b06396), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desloratadine/pseudoephedrine | Methyldopa | |
|---|---|---|
| Labeled for | Allergies | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.07 per tablet 12 hr 2.5-120 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once