What the FDA labels say about taking them together
Desipramine and haloperidol
Haloperidol's FDA label (Haloperidol Decanoate) of February 19, 2025 names desipramine in its drug interactions section; the desipramine labels PlainMeds reads (2) do not name haloperidol. The haloperidol label: “Plasma concentrations of CYP2D6 substrates may increase when they are co-administered with haloperidol.”
Check it at the source: the desipramine FDA label on DailyMed (effective July 9, 2025, Alembic Pharmaceuticals Inc.); the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.).
What does the desipramine label say about haloperidol?
Desipramine's label (effective July 9, 2025) and its 1 other brand-application label do not name haloperidol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DESIPRAMINE HYDROCHLORIDE), Alembic Pharmaceuticals Inc., effective July 9, 2025 (SPL set cad14805-64d8-4257-b5f1-d56e0063f0e2), via openFDA; the full label on DailyMed
What does the haloperidol label say about desipramine?
Haloperidol Decanoate label (Patriot Pharmaceuticals LLC, February 19, 2025), drug interactionsPlasma concentrations of CYP2D6 substrates (e, g. tricyclic antidepressants such as desipramine or imipramine) may increase when they are co-administered with haloperidol.
Source: FDA drug label (Haloperidol Decanoate, NDA018701), Patriot Pharmaceuticals LLC, effective February 19, 2025 (SPL set 9f0f42a8-5f7c-4be7-93ef-3ec225502cc6), via openFDA
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desipramine | Haloperidol | |
|---|---|---|
| Labeled for | Depression | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.276 per tablet 75 mg tablet | $15.60 per mL 100 mg/mL vial |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once