What the FDA labels say about taking them together
Deflazacort and efavirenz
Deflazacort's FDA label of November 13, 2025 names efavirenz in its drug interactions section; efavirenz's label does not name deflazacort itself but warns about its class (Corticosteroids). The deflazacort label: “Avoid concomitant use of strong (e.g., efavirenz) or moderate CYP3A4 inducers with EMFLAZA.”
Check it at the source: the deflazacort FDA label on DailyMed (effective November 13, 2025, PTC Therapeutics, Inc.); the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.).
What does the deflazacort label say about efavirenz?
Deflazacort label, drug interactionsAvoid concomitant use of strong (e.g., efavirenz) or moderate (e.g., carbamazepine, phenytoin) CYP3A4 inducers with EMFLAZA [see Dosage and Administration ( 2.5 ) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (EMFLAZA), PTC Therapeutics, Inc., effective November 13, 2025 (SPL set 31b347d2-f156-4055-9d8f-7cf0df420296), via openFDA; the full label on DailyMed
What does the efavirenz label say about deflazacort?
Efavirenz's label does not name deflazacort itself; it warns about its class (Corticosteroids):
Efavirenz label, warnings and precautionsEfavirenz should be discontinued in patients developing severe rash associated with blistering, desquamation, mucosal involvement, or fever. Appropriate antihistamines and/or corticosteroids may improve the tolerability and hasten the resolution of rash.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deflazacort | Efavirenz | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.28 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once