What the FDA labels say about taking them together
Defibrotide and heparin
Defibrotide's FDA label of July 1, 2025 names heparin in its drug interactions section; the heparin labels PlainMeds reads (4) do not name defibrotide.
Check it at the source: the defibrotide FDA label on DailyMed (effective July 1, 2025, Jazz Pharmaceuticals, Inc.); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).
What does the defibrotide label say about heparin?
Defibrotide label, drug interactionsDRUG INTERACTIONS Antithrombotic Agents DEFITELIO may enhance the pharmacodynamic activity of antithrombotic/fibrinolytic drugs such as heparin or alteplase.
Source: FDA drug label (DEFITELIO), Jazz Pharmaceuticals, Inc., effective July 1, 2025 (SPL set 2c3db989-d7ad-41ed-9ebf-698dcf6c24ec), via openFDA; the full label on DailyMed
What does the heparin label say about defibrotide?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name defibrotide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Defibrotide | Heparin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.18 per mL 5,000 unit/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once