What the FDA labels say about taking them together
Deferiprone and diclofenac
Deferiprone's FDA label of May 1, 2025 names diclofenac in its drug interactions section; the diclofenac labels PlainMeds reads (4) do not name deferiprone. The deferiprone label: “Drugs on Deferiprone Tablets UDP-Glucuronosyltransferases (UGTs): Avoid use of UGT1A6 inhibitors with deferiprone tablets.”
Check it at the source: the deferiprone FDA label on DailyMed (effective May 1, 2025, Hikma Pharmaceuticals USA Inc.); the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC).
What does the deferiprone label say about diclofenac?
Deferiprone label, drug interactionsDrugs on Deferiprone Tablets UDP-Glucuronosyltransferases (UGTs): Avoid use of UGT1A6 inhibitors (e.g., diclofenac, probenecid, or silymarin (milk thistle)) with deferiprone tablets [see Dosage and Administration ( 2.2 ), Adverse Reactions ( 6.1 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Ferriprox, NDA021825), Chiesi USA, Inc., effective January 28, 2026 (SPL set 946718ff-df43-1baa-74d1-e5bcfbe8ad86), via openFDA
Source: FDA drug label (Deferiprone), Hikma Pharmaceuticals USA Inc., effective May 1, 2025 (SPL set d7ea0a84-c328-4636-8cd6-ad75f2074b22), via openFDA; the full label on DailyMed
What does the diclofenac label say about deferiprone?
Diclofenac's label (effective February 11, 2025) and its 3 other brand-application labels do not name deferiprone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deferiprone | Diclofenac | |
|---|---|---|
| Labeled for | n/a | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0619 per tablet 75 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once