What the FDA labels say about taking them together
Deferasirox and tizanidine
Deferasirox's FDA label of January 28, 2026 names tizanidine in its drug interactions section; the tizanidine labels PlainMeds reads (3) do not name deferasirox. The deferasirox label: “Metabolized by CYP1A2 Deferasirox inhibits CYP1A2 resulting in an increase in CYP1A2 substrate concentration when these drugs are coadministered.”
Check it at the source: the deferasirox FDA label on DailyMed (effective January 28, 2026, Novartis Pharmaceuticals Corporation); the tizanidine FDA label on DailyMed (effective January 2, 2026, Legacy Pharma USA, Inc.).
What does the deferasirox label say about tizanidine?
Deferasirox label, drug interactionsMetabolized by CYP1A2 Deferasirox inhibits CYP1A2 resulting in an increase in CYP1A2 substrate (e.g., alosetron, caffeine, duloxetine, melatonin, ramelteon, tacrine, theophylline, tizanidine) concentration when these drugs are coadministered.
Source: FDA drug label (Exjade), Novartis Pharmaceuticals Corporation, effective January 28, 2026 (SPL set 3495a70c-870c-4968-940e-8baea152cf85), via openFDA; the full label on DailyMed
What does the tizanidine label say about deferasirox?
Tizanidine's label (effective January 2, 2026) and its 2 other brand-application labels do not name deferasirox in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zanaflex), Legacy Pharma USA, Inc., effective January 2, 2026 (SPL set 60c27d35-7349-4fc6-86ad-70fffdbe3e08), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deferasirox | Tizanidine | |
|---|---|---|
| Labeled for | n/a | Muscle spasms and spasticity |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.25 per tablet 360 mg tablet | $0.0331 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once