What the FDA labels say about taking them together
Daunorubicin and mitoxantrone
Mitoxantrone's FDA label of April 24, 2025 names daunorubicin in its warnings section; the daunorubicin labels PlainMeds reads (2) do not name mitoxantrone. The mitoxantrone label: “Cardiac Effects Because of the possible danger of cardiac effects in patients previously treated with daunorubicin or doxorubicin, the benefit-to-risk ratio of mitoxantrone injection therapy in such patients should be …”
Check it at the source: the daunorubicin FDA label on DailyMed (effective January 19, 2026, Hisun Pharmaceuticals USA, Inc.); the mitoxantrone FDA label on DailyMed (effective April 24, 2025, Meitheal Pharmaceuticals Inc.).
What does the daunorubicin label say about mitoxantrone?
Daunorubicin's label (effective January 19, 2026) and its 1 other brand-application label do not name mitoxantrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Daunorubicin Hydrochloride), Hisun Pharmaceuticals USA, Inc., effective January 19, 2026 (SPL set 9705fa12-499e-41a3-8fb4-f6df0858b851), via openFDA; the full label on DailyMed
What does the mitoxantrone label say about daunorubicin?
Mitoxantrone label, warningsCardiac Effects Because of the possible danger of cardiac effects in patients previously treated with daunorubicin or doxorubicin, the benefit-to-risk ratio of mitoxantrone injection therapy in such patients should be determined before starting therapy.
Source: FDA drug label (mitoXANTRONE), Meitheal Pharmaceuticals Inc., effective April 24, 2025 (SPL set 1634528a-30c5-4309-acc8-4c0293ae14ae), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Daunorubicin | Mitoxantrone | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once