What the FDA labels say about taking them together
Daunorubicin and methotrexate
Daunorubicin's FDA label of January 19, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name daunorubicin. The daunorubicin label: “Hepatotoxic medications, such as high-dose methotrexate, may impair liver function and increase the risk of toxicity.”
Check it at the source: the daunorubicin FDA label on DailyMed (effective January 19, 2026, Hisun Pharmaceuticals USA, Inc.); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the daunorubicin label say about methotrexate?
Daunorubicin label, drug interactionsHepatotoxic medications, such as high-dose methotrexate, may impair liver function and increase the risk of toxicity.
Source: FDA drug label (Daunorubicin Hydrochloride), Hisun Pharmaceuticals USA, Inc., effective January 19, 2026 (SPL set 9705fa12-499e-41a3-8fb4-f6df0858b851), via openFDA; the full label on DailyMed
What does the methotrexate label say about daunorubicin?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name daunorubicin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Daunorubicin | Methotrexate | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once