What the FDA labels say about taking them together
Darunavir and zolpidem
Darunavir's FDA label of August 29, 2025 names zolpidem in its drug interactions section; the zolpidem labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Titration is recommended when co-administering PREZISTA/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the darunavir label say about zolpidem?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: metabolized by CYP3A e.g. buspirone, diazepam, estazolam, zolpidem; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ sedatives/hypnotics; Clinical Comment: Titration is recommended when co-administering PREZISTA/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the zolpidem label say about darunavir?
Zolpidem's label (effective August 15, 2022) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Zolpidem | |
|---|---|---|
| Labeled for | HIV | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once