Darunavir and Triazolam Interaction
Drug interaction information between Darunavir and Triazolam.
Darunavir and Triazolam have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Darunavir and Triazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir blocks the body from breaking down triazolam, which can cause the sedative to build up to dangerous levels. This can lead to extreme sleepiness or trouble breathing.
FDA Label Information
Sedatives/hypnotics: orally administered midazolam, triazolam ↑ midazolam ↑ triazolam Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as prolonged or increased sedation or respiratory depression. Triazolam and orally administered midazolam are extensively metabolized by CYP3A. Co-administration of triazolam or orally administered midazolam with darunavir may cause large increases in the concentrations of these benzodiazepines.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Triazolam Also Interacts With
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Aprepitant moderate
- Clarithromycin moderate
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Triazolam?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Triazolam's 10. In the major band specifically: Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide); Triazolam has 3 (also Itraconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Darunavir and Triazolam?
Darunavir blocks the body from breaking down triazolam, which can cause the sedative to build up to dangerous levels. This can lead to extreme sleepiness or trouble breathing.
Darunavir carries more major-labeled pairs than Triazolam
SPL source-record counts only. This page's band is major · classes on file: Darunavir (HIV Protease Inhibitor); Triazolam (Benzodiazepine (Hypnotic)).
Darunavir has 15 major-labeled pairs vs Triazolam's 3.
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
3 major · 2 moderate · 5 minor · 10 total
- Other major peers for Triazolam
- Itraconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.