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What the FDA labels say about taking them together

Darunavir and triamcinolone

Darunavir's FDA label of August 29, 2025 names triamcinolone in its drug interactions section; the triamcinolone labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Co-administration with corticosteroids of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …”

Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the triamcinolone FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).

What does the darunavir label say about triamcinolone?

Darunavir label, drug interactions

Concomitant Drug Class Drug Name Examples: Corticosteroids primarily metabolized by CYP3A: e.g. betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ corticosteroids; Clinical Comment: Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …

Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed

What does the triamcinolone label say about darunavir?

Triamcinolone's label (effective January 28, 2026) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (triamcinolone acetonide), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set 92a1ded0-8e1a-4994-9c8a-89e84fc85c94), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

13Darunavir generic labelers
73Triamcinolone generic labelers
DarunavirTriamcinolone
Labeled forHIVAsthma, Eczema (atopic dermatitis), Anemia, Leukemia, lymphoma and myeloma, Allergies, Fever, Pain, Osteoarthritis
Boxed warningNoNo
Pharmacy cost (NADAC)$1.16 per tablet 600 mg tablet$0.0452 per gram 0.1% cream
Shortage nowNo current entryListed; available

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?