What the FDA labels say about taking them together
Darunavir and tramadol
Darunavir's FDA label of August 29, 2025 names tramadol in its drug interactions section; the tramadol labels PlainMeds reads (3) do not name darunavir. The darunavir label: “A dose decrease may be needed for tramadol with concomitant use.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the tramadol FDA label on DailyMed (effective March 5, 2026, Lupin Pharmaceuticals, Inc.).
What does the darunavir label say about tramadol?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: tramadol; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ tramadol; Clinical Comment: A dose decrease may be needed for tramadol with concomitant use.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the tramadol label say about darunavir?
Tramadol's label (effective March 5, 2026) and its 2 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TRAMADOL HYDROCHLORIDE), Lupin Pharmaceuticals, Inc., effective March 5, 2026 (SPL set 46bb9ae6-3ee8-463c-badb-c7a45a89b84b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Tramadol | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.0248 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once