What the FDA labels say about taking them together
Darunavir and tacrolimus
Darunavir's FDA label of August 29, 2025 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Therapeutic concentration monitoring of the immunosuppressive agent is recommended when co-administered with PREZISTA/ritonavir.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the darunavir label say about tacrolimus?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Immunosuppressants: e.g. cyclosporine, tacrolimus, sirolimus; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ immunosuppressants; Clinical Comment: Therapeutic concentration monitoring of the immunosuppressive agent is recommended when co-administered with PREZISTA/ritonavir.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the tacrolimus label say about darunavir?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Tacrolimus | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once