Darunavir and Ranolazine Interaction

Drug interaction information between Darunavir and Ranolazine.

Darunavir and Ranolazine have a documented major interaction in FDA labeling.

FDA drug labeling documents a major-severity interaction between Darunavir and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Darunavir

HIV Protease Inhibitor

Drug B

Ranolazine

Late Sodium Current Inhibitor (Antianginal)

How They Interact

Darunavir stops your body from processing ranolazine correctly, which leads to high levels of the drug in your system. This can cause serious or life-threatening side effects.

FDA Label Information

Cardiac Disorders : ranolazine, ivabradine ↑ ranolazine ↑ ivabradine Co-administration is contraindicated due to potential for serious and/or life-threatening reactions.

Frequently Asked Questions

What SPL severity band is on file for Darunavir + Ranolazine?

Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Darunavir has 101 labeled pairs on file vs Ranolazine's 31. In the major band specifically: Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide); Ranolazine has 12 (also Ketoconazole, Carbamazepine, Clarithromycin, Rifampin).

What mechanism field is on file for Darunavir and Ranolazine?

Darunavir stops your body from processing ranolazine correctly, which leads to high levels of the drug in your system. This can cause serious or life-threatening side effects.

Darunavir carries more major-labeled pairs than Ranolazine

SPL source-record counts only. This page's band is major · classes on file: Darunavir (HIV Protease Inhibitor); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).

Darunavir has 15 major-labeled pairs vs Ranolazine's 12.

Darunavir

15 major · 16 moderate · 70 minor · 101 total

Ranolazine

12 major · 7 moderate · 12 minor · 31 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.