What the FDA labels say about taking them together
Darunavir and prednisone
Darunavir's FDA label of August 29, 2025 names prednisone in its drug interactions section; the prednisone label PlainMeds reads does not name darunavir. The darunavir label: “… adrenal suppression. Alternative corticosteroids including beclomethasone, prednisone, and prednisolone should be considered, particularly for long term use.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the prednisone FDA label on DailyMed (effective April 22, 2025, Hikma Pharmaceuticals USA Inc.).
What does the darunavir label say about prednisone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Corticosteroids primarily metabolized by CYP3A: e.g. betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ corticosteroids; Clinical Comment: Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the prednisone label say about darunavir?
Prednisone's label (effective April 22, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PredniSONE), Hikma Pharmaceuticals USA Inc., effective April 22, 2025 (SPL set 3115aef0-fd50-4ec8-a064-3effb695f3f2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Prednisone | |
|---|---|---|
| Labeled for | HIV | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Eczema (atopic dermatitis), Anemia, Organ transplant rejection |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.0643 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once