What the FDA labels say about taking them together
Darunavir and oxycodone
Darunavir's FDA label of August 29, 2025 names oxycodone in its drug interactions section; the oxycodone labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Careful monitoring of therapeutic effects and adverse reactions associated with CYP3A-metabolized narcotic analgesics is recommended with co-administration.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the oxycodone FDA label on DailyMed (effective May 6, 2026, Rhodes Pharmaceuticals LLC).
What does the darunavir label say about oxycodone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: e.g. fentanyl, oxycodone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ fentanyl ↑ oxycodone; Clinical Comment: Careful monitoring of therapeutic effects and adverse reactions associated with CYP3A-metabolized narcotic analgesics (including potentially fatal respiratory depression) is recommended with co-administration.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the oxycodone label say about darunavir?
Oxycodone's label (effective May 6, 2026) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Oxycodone Hydrochloride), Rhodes Pharmaceuticals LLC, effective May 6, 2026 (SPL set a5162476-1217-41c0-bc7e-0a0f123f069f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Oxycodone | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.0884 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once