What the FDA labels say about taking them together
Darunavir and nortriptyline
Darunavir's FDA label of August 29, 2025 names nortriptyline in its drug interactions section; the nortriptyline label PlainMeds reads does not name darunavir. The darunavir label: “Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the nortriptyline FDA label on DailyMed (effective December 4, 2024).
What does the darunavir label say about nortriptyline?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: amitriptyline, desipramine, imipramine, nortriptyline; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ amitriptyline ↑ desipramine ↑ imipramine ↑ nortriptyline; Clinical Comment: Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the nortriptyline label say about darunavir?
Nortriptyline's label (effective December 4, 2024) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PAMELOR), SpecGx LLC, effective December 4, 2024 (SPL set e17dc299-f52d-414d-ab6e-e809bd6f8acb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Nortriptyline | |
|---|---|---|
| Labeled for | HIV | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.113 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once